Keywords: Alzheimer's Disease, Alzheimer's DiseaseAlzheimer’s is an irreversible degenerative brain disease. Clinical MRI may visualize severe brain atrophy but fails to recognize earlier biomarkers associated with subtle microstructural changes. Microstructural MRI techniques such as DTI, MAP-MRI, and MSDKI may sensitively detect and distinguish tissue degeneration, tauopathies, and beta amyloid plaques in the hippocampus and entorhinal cortex. The capability of these techniques was investigated in post-mortem human temporal lobe specimens at high resolution and high image quality. Prominent findings seen were differences between DTI and MAP-MRI anisotropy metrics, and striking differences between the hippocampus and entorhinal cortex for restriction due to plaques.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords