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Abstract #3509

Development of an FOD template of the older adult brain for the MIITRA atlas

Yingjuan Wu1, Abdur Raquib Ridwan2, Mohammad Rakeen Niaz1, David A. Bennett2, and Konstantinos Arfanakis1,2
1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, United States

Synopsis

Keywords: Alzheimer's Disease, Aging, AtlasA high quality FOD template of the older adult brain can enhance the sensitivity and accuracy of white matter investigations in older adults. The present work compared several FOD template construction methods for the purpose of developing a high-resolution FOD template of the older adult brain in the space of the MIITRA atlas. The preferred method employed multichannel registration based on T1w, FA and FOD information, followed by additional FOD single modality registration. The resulting FOD template exhibited high image quality, was constructed based on precisely matched FOD data, and exhibited high spatial matching to other existing MIITRA templates.

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Keywords