Keywords: Alzheimer's Disease, Alzheimer's Disease, ApoE4; genetic-riskWe have recently shown that the functional connectivity of the left hippocampus is significantly related to memory trajectory in cognitively intact ApoE4 carriers, independent of hippocampal volume. The purpose of this preliminary study was to determine if dendritic orientation dispersion of the left hippocampus explains variance in delayed verbal memory in this cohort. Results indicated that dendritic complexity of the left hippocampus was related to delayed memory in ApoE4 carriers. These findings suggest that ApoE4 carriers may experience subtle microstructural declines in the left hippocampus at the cognitively-intact stage.
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