Abstract #3512

White matter fiber characteristics in Alzheimer's disease using fixel-based analysis

Meng Li¹, Shanwen Liu², Yuqi Zhi¹, Rong Liu¹, Zhen Jiang¹, Xiaoyun Liang^3,4, Hua Hu², Yunzhu Wu⁵, Yang Song⁵, and Jiangtao Zhu¹

¹Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China, ²Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China, ³Institute of Artificial Intelligence and Clinical Innovation, Neusoft Medical Systems Co., Ltd., Shanghai, China, ⁴Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia, ⁵MR Scientific Marketing, SIEMENS Healthineers Ltd., Shanghai, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's DiseaseWe collected diffusion-weighted images of all subjects and divided them into four groups: HC, MCI, mild AD and moderate AD. The differences of FD, FC and FDC were analyzed by FBA method. The results showed that the three metrics in AD group were significantly lower than those in HC Group, but there was no significant difference in MCI Group. This study indicates that there is a microstructural or macrostructural degeneration in the white matter of AD patients.

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