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Abstract #3520

Development of a high-resolution magnetic susceptibility template of the older adult brain in MIITRA space

Rasheed Abid1, Abdur Raquib Ridwan2, Yingjuan Wu1, Mohammad Rakeen Niaz1, Shengwei Zhang2, Arnold M. Evia2, David A. Bennett2, and Konstantinos Arfanakis1,2
1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, United States

Synopsis

Keywords: Alzheimer's Disease, Aging, Brain, Susceptibility, AtlasQuantitative susceptibility mapping (QSM) is considered a promising tool for the detection and monitoring of disease processes that alter magnetic susceptibility in the brain of older adults. Voxel-wise and atlas-based QSM analyses require accurate spatial normalization of QSM data, which requires a high quality QSM template representative of the population. However, a QSM template of the older adult brain is not yet available. This study aimed to construct a high quality, high resolution QSM template of the older adult brain in the space of the MITRA atlas based on data from a large, diverse, community cohort of non-demented older adults.

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Keywords