Abstract #3521

Measurement of blood-brain barrier leakage in AD transgenic mice with aging: Improving sensitivity with capillary input function

Jonghyun Bae^1,2,3, Ayesha Das³, Isabel Reyes⁴, Sawwal Qayyum⁵, Jin Zhang⁵, Arjun Masurkar⁴, and Sungheon Gene Kim⁵

¹Vilcek Institute of Graduate Biomedical Science, NYU School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research, Radiology, NYU School of Medicine, New York, NY, United States, ³Radiology, Weill Cornell Medical College, New York, NY, United States, ⁴Neurology, NYU Langone Health, New York, NY, United States, ⁵Weill Cornell Medical College, New York, NY, United States

Synopsis

Keywords: Alzheimer's Disease, AgingRecent studies have suggested that the increase in blood-brain barrier (BBB) permeability is associated with both aging and the progression of the Alzheimer’s disease (AD). However, the association of the amyloid pathology with the increased BBB leakage at different disease progression is still poorly understood. In this study, we performed a cross-sectional study to investigate the BBB permeability changes in AD transgenic mice with aging. We also propose the network-aided analysis allows the scan time reduction without compromising the accuracy of the detection of the subtle permeability

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