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Abstract #3531

Dexmedetomidine Administration in a Rat Model of Kaolin-induced Hydrocephalus

Meltem Karatas1, Diaa K.A. Yahya2, Merve Ayan3, Sevda Muftuoglu3, Kader Karli Oguz1,4,5, and Halil Kamil Oge2
1National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Turkey, 2Department of Neurosurgery, Hacettepe University, Ankara, Turkey, 3Department of Histology and Embryology, Hacettepe University, Ankara, Turkey, 4Department of Radiology, Hacettepe University, Ankara, Turkey, 5Department of Radiology, University of California, Davis, Sacramento, CA, United States

Synopsis

Keywords: Neuroinflammation, Translational Studies, Hydrocephalus , dexmedetomidineHydrocephalus is defined as an abnormal enlargement of cerebral ventricles due to disturbed cerebrospinal fluid (CSF) dynamics. It is characterized by neuroinflammatory processes in the brain parenchyma and CSF, with pathological findings including reactive gliosis, axonal and neuronal damage, and loss of myelin sheaths. The use of anti-inflammatory medications in hydrocephalus may be an effective treatment strategy for neuroprotection. In this study, we used a rat model of hydrocephalus induced by kaolin. We aimed to demonstrate the potential anti-inflammatory and neuroprotective effects of dexmedetomidine on hydrocephalic brains using MRI and morphometric analysis.

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