Abstract #3532

Quantitative susceptibility source separation improves the reader agreement in the identification of MS paramagnetic rim lesions

Emily Demmon¹, Susan Gauthier¹, Ilhami Kovanlikaya², Yi Wang², Alexey Dimov², Pascal Spincemaille², and Thanh Nguyen²

¹Department of Neurology, Weill Cornell Medicine, New York City, NY, United States, ²Department of Radiology, Weill Cornell Medicine, New York City, NY, United States

Synopsis

Keywords: Multiple Sclerosis, NeuroscienceMultiple Sclerosis (MS) is an autoimmune disorder characterized by focal inflammatory demyelination. Paramagnetic rim lesions (PRLs) form an important subset of chronic active MS lesions that show a hypocellular core and persistent glial inflammation and continuing myelin damage at the rim on histopathology. PRLs are a critical clinical target for MS therapy. Our goal in this project is to improve overall detection of PRLs through utilization of quantitative paramagnetic source maps.

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