Keywords: Multiple Sclerosis, Molecular Imaging, USPIO
While the specific pathologic mechanisms that underpin ongoing axonal loss in progressive forms of MS are not fully characterized, ongoing innate immune activation in chronic MS lesions, particularly activated microglia and macrophages, has been proposed to be a prevailing mechanism of axonal loss in the progressive phase of disease. Ultrasmall superparamagnetic iron oxide particles have been introduced as a potential MRI biomarker for macrophage activity in focal MS lesions. This work presents a Feromoxytol enhanced MRI to measure perilesional activated microglia and macrophages in progressive MS. which is anticipated to reflect risk for ongoing loss of CNS axons and neurons.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords