Abstract #3534

Nonsusceptibility frequency shift reveals subtypes of multiple sclerosis lesions and predicts 5-year disappearance of paramagnetic rim

Thomas Jochmann^1,2, Jack A. Reeves², Fahad Salman², Dejan Jakimovski², Simon Hametner³, Maryam Mohebbi², Niels Bergsland², Bianca Weinstock-Gutman⁴, Michael G. Dwyer², Robert Zivadinov^2,5, Jens Haueisen¹, and Ferdinand Schweser^2,5

¹Department of Computer Science and Automation, Technische Universität Ilmenau, Ilmenau, Germany, ²Buffalo Neuroimaging Analysis Center, Department of Neurology at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ³Department of Neuroimmunology, Medical University of Vienna, Vienna, Austria, ⁴Jacobs Multiple Sclerosis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ⁵Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States

Synopsis

Keywords: White Matter, Multiple SclerosisMultiple sclerosis lesions have different types and stages that are challenging to distinguish by conventional MRI. We recently presented DEEPOLE QUASAR, a reconstruction technique that yields nonsusceptibility frequency maps as a novel MRI contrast. In this study, we translate the novel contrast into a tool for multiple sclerosis lesion assessment. We discuss the time course of nonsusceptibility frequency throughout different lesion stages. Within different paramagnetic rim lesions that are typically indistinguishable by conventional MRI, the nonsusceptibility frequency contrast showed hypo-, iso-, and hyperintense subtypes. At a 5-year follow-up, paramagnetic rims disappeared at significantly different proportions between these subtypes.

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