Keywords: Spinal Cord, CEST & MTWe identified molecular pools of interest using CEST imaging of rats after spinal cord injury (SCI) that correlate with post-SCI behavioral deficits, and which may indicate products of neuroinflammation. Using tissue neurochemical analysis, we isolated analytes of interest and acquired CEST Z-spectra from solutions of the chemicals to elucidate the source of the CEST pool concentration changes. Several candidates present in the tissue samples showed similar (overlapping) Z-spectra around 3.0 ppm. These results suggest that CEST imaging is not specific for identifying concentration changes of individual molecules of interest.
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