Abstract #3541

¹H fMRS detects changes in dorsal anterior cingulate cortex glutamate driven by inhibitory control

Jillian M. Eichstaedt¹, Dalal Khatib², Phil Easter², David R. Rosenberg², Vaibhav A. Diwadkar², and Jeffrey A. Stanley³

¹Translational Neuroscience Program, Wayne State University School of Medicine, Detroit, MI, United States, ²Wayne State University School of Medicine, Detroit, MI, United States, ³Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine, Detroit, MI, United States

Synopsis

Keywords: Psychiatric Disorders, Spectroscopy, Inhibitory Control

¹H fMRS was used to quantify changes in dACC glutamate evoked during excitatory and inhibitory motor control. The two response modes demanded non-selective responding (motor control with excitation) or selective responding (motor control with inhibition). dACC glutamate was significantly increased (relative to a resting baseline), regardless of response mode. These functional responses (uncoupled from hemodynamics) demonstrate that ¹H fMRS can be successfully used to reveal glutamate related mechanisms of the dACC reflecting changes in the excitatory neurotransmission drive.

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