Abstract #3542

Inhomogeneous Magnetization Transfer (ihMT) of Peripheral Nerve in Patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Ryuna Kurosawa¹, Hajime Yokota², Takayuki Sada¹, Koji Matsumoto¹, Takafumi Yoda¹, Masami Yoneyama³, Takashi Namiki³, Guillaume Gilbert⁴, Yoshitada Masuda¹, and Takashi Uno²

¹Department of Radiology, Chiba university hospital, Chiba, Japan, ²Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan, ³Philips Japan, Tokyo, Japan, ⁴Philips Canada, Mississauga, ON, Canada

Synopsis

Keywords: Neurodegeneration, CEST & MTChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated demyelinating disease. The purpose of this study is to evaluate the usefulness of ihMT in the diagnosis of CIDP by measuring myelin levels using ihMT imaging. ihMTR of the sciatic nerve of CIDP patients was significantly lower than that of the normal subjects. Our finding was compatible with previously reported pathological changes. Myelin imaging by ihMT has the potential to be used as a new biomarker in the diagnosis of CIDP.

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