Abstract #3543

MRI of Neuroinflammation in the Brain following Meth Addiction using Multiplied, Added, Subtracted and/or Divided (MASDIR) sequences.

Paul Condron^1,2, Maryam Tayebi^1,2, Taylor Emsden^1,2, Ben Bristow^1,3, Tuta Ngārimu^4,5, Patrick McHugh^1,6, Gil Newburn¹, Davidson Taylor^1,7, Samantha Holdsworth^1,2, Daniel Cornfeld^1,2, Miriam Scadeng^1,2, and Graeme Bydder^1,8

¹Mātai Medical Research Institute, Gisborne, New Zealand, ²Faculty of Medical and Health Sciences & Centre for Brain Research, Auckland, New Zealand, ³Department of Neuroscience,, University of Otago, Dunedin, New Zealand, ⁴New Zealand P Pull, Tairāwhiti-Gisborne, New Zealand, ⁵Ngati Porou, Aotearoa, New Zealand, ⁶Tūranga Health, Tūranganui-a-kiwa, Gisborne, New Zealand, ⁷Ngāti Porou, Ngāti Kahungungu, Rongomaiwahine, Rongowhakaata; Tūranganui-a-Kiwa, Tairāwhiti, New Zealand, ⁸University of California San Diego, San Diego, CA, United States

Synopsis

Keywords: Neuroinflammation, Drugs, brain, methamphetamine, white matter hyper intensities

Keywords; Neuroinflammation, data acquisition and post processing, contrast mechanisms, white matter, drugs.

MR contrast can be enhanced by exploiting the concept of tissue property filters (TPFs) by designing Multiplied, Added, Subtracted, and/or Divided Inversion Recovery (MASDIR) sequences to amplify contrast produced by small changes in white matter T1. The Divided, Subtracted IR (dSIR) sequence provides very high contrast depiction of subtle white matter changes due to disease that are not identified with standard T2-FLAIR imaging. This was demonstrated in patients with a history of methamphetamine addiction. MASDIR sequences could revolutionize the way that neuroinflammation is imaged in clinical practice.

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