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Abstract #3545

Assessing the effects of hyperpolarized [2-13C]lactate saturation on detectable brain metabolism

Adam Autry1, Sana Vaziri1, Hsin-Yu Chen1, Yaewon Kim1, Duey Dang1, Javier Villanueva-Meyer1, Susan M Chang2, Jennifer Clarke2, Nancy A Oberheim-Bush2, Robert Bok1, Duan Xu1, Janine M Lupo1, Daniel B Vigneron1, Jeremy Gordon1, and Yan Li1
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Gray Matter, Hyperpolarized MR (Non-Gas), metabolismFollowing hyperpolarized [1-13C]pyruvate MRI studies that demonstrated insights into brain metabolism using saturation experiments, this study sought to assess whether metabolic pathways probed by [2-13C]pyruvate could similarly be interrogated. Our investigation showed that not exciting [2-13C]lactate led to a 2-fold increase in [5-13C]glutamate signal, which may indicate compartmentalized metabolism in the brain.

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