Abstract #3547

Cerebral Blood Flow quantification in anesthetized macaque using pseudo-continuous Arterial Spin Labeling at 3T

Leyre Garcia-Ruiz^1,2, Karol M. Córdoba³, Daniel Jericó³, Maite Aznárez-Sanado⁴, Marta Vidorreta⁵, Antonio Fontanellas³, and Maria A. Fernández-Seara^1,2

¹Radiology, Clínica Universidad de Navarra, Pamplona, Spain, ²IdiSNA,Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain, ³Hepatology, CIMA Universidad de Navarra, Pamplona, Spain, ⁴School of Education and Psychology Universidad de Navarra, Pamplona, Spain, ⁵Siemens Healthcare, Madrid, Spain

Synopsis

Keywords: Gray Matter, Arterial spin labelling, Animal, Preclinical, White MatterA pseudo-continuous arterial spin labeling (pCASL) technique was implemented on a Siemens 3T Skyra for quantitative cerebral blood flow (CBF) measurements in non-human primates (rhesus monkeys). Different regions were manually segmented based on T1 weighted images. ASL images were obtained in 10 min with 2.2-mm isotropic resolution. Whole brain CBF was 32.40±14.61 ml/100g/min (n=8) for female and 44.28±24.61 ml/100 g/min for male (n=4) rhesus monkeys under ketamine and midazolam anesthesia. Gender differences of CBF among brain regions will be address in this study.

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