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Abstract #3552

Altered patterns of brain iron deposition in end-stage renal disease patients with depression

Yuan Li1, Yuhan Jiang1, Bingbing Gao1, Mingrui Qu1, Liangjie Lin2, Qingwei Song1, and Yanwei Miao1
1the First Affiliated Hospital of Dalian Medical University, Dalian, China, 2Philips Healthcare, Beijing, China

Synopsis

Keywords: Gray Matter, KidneyBoth depression and end-stage renal disease (ESRD) may affect the pattern of iron deposition in human brain. This study aimed to quantify the changes of brain iron deposition in ESRD patients with and without depression using quantitative susceptibility mapping, and to further explore the effect of depression on iron deposition pattern in ESRD patients. Results showed that ESRD patients had increased brain iron deposition compared with heathy controls, especially in the left putamen and the right red nucleus, and ESRD patients with depression had less increase in iron deposition than those without depression.

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