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Abstract #3555

T2 heterogeneity of cortex in patients with beta-thalassemia major

Xi Deng1, Meiru Bu1, Meiqing Wu2, Wei Cui3, Long Qian3, Zisan Zeng1, and Muliang Jiang1
1Radiology Department of the First Affiliated Hospital of Guangxi Medical University, Nanning, China, 2Hematology Department of The First Affiliated Hospital of Guangxi Medical University, Nanning, China, 3MR Research, GE Healthcare, Beijing, China, Beijing, China

Synopsis

Keywords: Gray Matter, Blood, Beta-thalassemia; T2 heterogeneity;Beta-thalassemia (β-TM) is an inherited blood disorder with severe anemia. In this study, we investigated alterations of T2 heterogeneity in cortical regions caused by β-TM using magnetic resonance imaging (MRI). Compared with healthy controls, β-TM patients showed increased T2 heterogeneities in bilateral inferior orbitofrontal, left calcarine, left cuneus and left superior occipital lobe, while no decreased T2 heterogeneity was observed. Thus, we concluded that T2 heterogeneities could reveal the β-TM-affecting T2 alterations in brain.

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