Abstract #3561

Brain structures of a human embryo depicted by MR microscopy with different contrasts

Kazuki Kunieda¹, Kazuyuki Makihara¹, Shigehito Yamada², and Yasuhiko Terada¹

¹Graduate School of Science and Technology, University of Tsukuba, Tsukuba, Japan, ²Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan

Synopsis

Keywords: Brain Connectivity, MicrostructureBrain structures of human embryos are several tens of micrometers in size, and MR microscopy is essential for elucidating human embryos. However, conventional fast T1-weighted imaging could not delineate some critical structures. In this study, T1, T2, and T2* values were measured to simulate the contrast of each tissue of the human embryo brain, and MR images were acquired at the extremely high resolution of (30 μm)³ using pulse sequences that emphasized the contrast difference in the brain structures. This technique would unveil the three-dimensional microstructure and developmental process of the brain’s central nervous system in its early stages.

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