Abstract #3565

An Optimized High Resolution Acquisition and Processing Pipeline for QSM in the Prostate

Laxmi Muralidharan¹, Manju Mathew², Joey Clemente², Lucy Caselton², Sumandeep Kaur², Mrishta Brizmohun², Shonit Punwani², and Karin Shmueli¹

¹Dept of Medical Physics and Bioengineering, University College London, London, United Kingdom, ²Centre for Medical Imaging, University College London, London, United Kingdom

Synopsis

Keywords: Quantitative Imaging, Susceptibility, Background field removal

We aimed to optimize MRI acquisition with 1mm isotropic resolution and Quantitative Susceptibility Mapping (QSM) reconstruction for prostate clinical research. Acquisition parameters optimized in two subjects included fat-water phase artifact removal, parallel imaging acceleration factor, resolution and number of echoes. QSM masking, background field removal and susceptibility calculation were optimized in six subjects and three prostatectomy specimens. In-phase acquisition removed more fat-water phase artifacts than post-processing. VSHARP and excluding rectal gas reduced residual background fields and Iterative Tikhonov regularization reduced noise. This optimized (8.5 minute) protocol and pipeline will allow incorporation of prostate QSM in clinical research studies.

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