Abstract #3566

Quantitative evaluation of deep gray matter in striatal-cerebellar-brainstem circuits in Parkinson’s disease patients with freezing of gait

Youmin Zhang¹, Naying He¹, Zhijia Jin ¹, Yu Liu¹, Xinhui Wang¹, E. Mark Haacke^1,2, and Fuhua Yan¹

¹Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Department of Radiology, Wayne State University, Detroit, MI, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative Susceptibility mappingThis study evaluated the structural changes of the deep gray matter in the cortico-basal ganglia and cerebellar motor circuit in Parkinson’s disease patients with freezing of gait. Using region-of-interest-based quantitative susceptibility mapping analysis, we found pronounced striatum atrophy combined with caudal substantia nigra abnormal iron accumulation in Parkinson’s disease patients with freezing of gait. This result offered new insight into future research investigating the pathophysiology of the freezing of gait.

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