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Abstract #3567

Magnetic Susceptibility Separation Reveals Longitudinal Lesion Changes in Multiple Sclerosis

Ziyan Zhu1, Javad Hamidi Esfahani1, Nashwan Naji1, Peter Seres1, Derek Emery2, Gregg Blevins3, Penelope Smyth3, and Alan Wilman1,2
1Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, 3Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada

Synopsis

Keywords: Multiple Sclerosis, Multiple Sclerosis, Iron Change, Myelin ChangeSusceptibility separation may distinguish iron and myelin in multiple sclerosis (MS) lesions, but little work has been done on longitudinal changes. Twenty MS subjects were followed for 14 months to investigate para and diamagnetic changes independently using susceptibility separation in comparison to transverse relaxation and susceptibility mapping. Susceptibility separation provided distinction between myelin and iron events, offering more insight into MS lesion evolution.

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