Abstract #3569

BTX: Simultaneous 3D Quantitative Magnetization Transfer Imaging and Susceptibility Mapping

Albert Jang^1,2, Hyungseok Jang³, and Fang Liu^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA, United States, ²Radiology, Massachusetts General Hospital, Boston, MA, United States, ³Radiology, University of California, San Diego, San Diego, CA, United States

Synopsis

Keywords: Quantitative Imaging, Multi-Contrast, Magnetization Transfer, Quantitative Susceptibility MappingWe propose a novel sequence that enables simultaneous quantitative magnetization transfer (qMT) imaging and susceptibility mapping (QSM) for assessing tissue composition, microstructure, and microenvironment. We extend our BTS sequence to incorporate a multi-echo acquisition scheme for probing tissue susceptibility information. The acquisition allows quantification of B₁⁺, bias-corrected T₁, qMT parameters (macromolecule bound proton fraction and proton exchange rate), tissue susceptibility and T₂^*. The method’s feasibility is demonstrated using an in-vivo brain scan, where 3D concurrent qMT and QSM were obtained for the whole brain at feasible scan time.

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