Keywords: Quantitative Imaging, Susceptibility, Multiple Sclerosis, Animal ModelsThere is evidence for changes in magnetic susceptibility in the CNS of people with MS. MRI techniques utilizing relaxometry and magnetic tissue properties – R2* and quantitative susceptibility mapping, respectively – can be used to detect these changes. Both techniques were applied to study pathological changes in EAE mice compared to controls. Significant differences were found in the cortex between EAE mice and controls using R2*, while no differences in magnetic susceptibility were found between the two groups. Although this indicates that R2* may be better at detecting differences, perhaps it can be utilized as a complement to QSM analysis.
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