Abstract #3576

Brain iron content increase and oxygen extraction fraction reduction after iron repletion in blood donation induced iron deficiency

Hangwei Zhuang^1,2, Alexey Dimov³, Gary Brittenham⁴, Pascal Spincemaille³, Thanh Nyugen³, Yi Wang³, and Eldad Hod⁴

¹Biomedical Engineering, Cornell University, Ithaca, NY, United States, ²Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States, ³Weill Medical College of Cornell University, New York, NY, United States, ⁴Columbia University Medical Center, New York, NY, United States

Synopsis

Keywords: Hematologic, Neuro

We examined brain iron content using susceptibility source separation and oxygen extraction fraction (OEF) in adult healthy blood donors with blood donation-induced iron deficiency treated with intravenous iron repletion at the first donation and a second donation after approximately 5 months and compared it with a control group who was not treated after the first donation. Iron content increases in the parietal cortex, the caudate and the putamen were observed in the treatment group. OEF reduction was observed in the whole brain and multiple ROIs, suggesting iron repletion treatment helps reduce oxidative stress.

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