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Abstract #3577

Brain iron status in children and adolescents with beta-thalassemia.

Daniil Kirdyashkin1, Vera Lopatina1, Petr Bulanov1,2, Natalia Kriventsova1, Galina Tereshchenko1, and Petr Menshchikov1,2
1Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation, 2Philips, Moscow, Russian Federation

Synopsis

Keywords: Quantitative Imaging, Quantitative Susceptibility mapping, Iron accumulation

Background TDT patients are susceptible to secondary iron overload. Determining brain iron content may be crucial to prevent brain iron poisoning. TDT Patient and control groups consisted of 23 and 50 children and adolescents respectively. 3D, T1-weighted and susceptibility-weighted images were obtained and QSM maps were reconstructed. Magnetic susceptibility values in brain structures were adjusted for age-related iron accumulation. Statistical analysis, carried out with and without correction for age, did not reveal significant differences in brain iron content between the two groups. Brain iron overload does not occur in TDT patients, whether it be children or adults.

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Keywords