Keywords: Quantitative Imaging, Quantitative Susceptibility mapping, Iron accumulation
Background TDT patients are susceptible to secondary iron overload. Determining brain iron content may be crucial to prevent brain iron poisoning. TDT Patient and control groups consisted of 23 and 50 children and adolescents respectively. 3D, T1-weighted and susceptibility-weighted images were obtained and QSM maps were reconstructed. Magnetic susceptibility values in brain structures were adjusted for age-related iron accumulation. Statistical analysis, carried out with and without correction for age, did not reveal significant differences in brain iron content between the two groups. Brain iron overload does not occur in TDT patients, whether it be children or adults.
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