Abstract #3582

Myelin Measurement: Comparison Between Simultaneous Relaxometry, Inhomogeneous Magnetization Transfer Imaging, and Myelin Water Fraction

Moto Nakaya^1,2, Akifumi Hagiwara¹, Masanori Ozaki³, Hiroshi Kusahara³, Yasunobu Hoshino⁴, Yuji Tomizawa⁴, Kazumasa Yokoyama⁴, Shohei Fujita^1,2, Christina Andica¹, Koji Kamagata¹, Masaaki Hori^1,5, Akihiko Wada¹, Osamu Abe², and Shigeki Aoki¹

¹Department of Radiology, Juntendo University, Tokyo, Japan, ²Department of Radiology, The University of Tokyo, Tokyo, Japan, ³Canon Medical Systems Corporation, Kawasaki, Japan, ⁴Department of Neurology, Juntendo University, Tokyo, Japan, ⁵Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan

Synopsis

Keywords: Multiple Sclerosis, ValidationIn 16 healthy adults, we examined the correlation between three MR myelin measurement methods, including myelin volume fraction (MVF) measured with simultaneous tissue relaxometry of R1 and R2 relaxation rates and proton density, inhomogeneous magnetization transfer imaging (ihMT), and myelin water fraction (MWF). A strong correlation was obtained between ihMT and MVF, and MWF was less correlated with the others. We should be mindful that these metrics are measuring different aspects of “myelin”.

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