Abstract #3584

**Comparison of myelin water fraction mapping on ex vivo human brain at 3T and 7T**

Guojun Xu¹, Zhiyong Zhao¹, Qinfeng Zhu¹, Zuozhen Cao¹, Keqing Zhu^2,3, Jing Zhang^2,3, and Dan Wu¹

¹Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, ²China Brain Bank and Department of Neurology in Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, ³Department of Pathology, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Quantitative Imaging, White Matter

Multi-echo gradient-echo (mGRE) is an important method to quantify myelin water fraction (MWF) of the human brain, but the results may depend on field strength given the difference in T2*. This study performed mGRE-based MWF on ex vivo human brain at high resolution at both 3T and 7T. We found MWF-derived from 7T showed higher measurements with lager standard deviations compared to those 3T, and the 3T and 7T results showed moderate agreement. These findings indicated the MWF mapping result was field-strength dependent and further validations were needed to support their reliability.

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