Abstract #3585

Ultra rapid volumetric imaging for diagnosis in memory clinic: assessment of white matter hyperintensities quantification

Carole Helene Sudre^1,2, Haroon R Chughtai², David L Thomas^3,4, David Cash⁴, Miguel Rosa-Grilo⁴, Millie Beament⁴, Frederik Barkhof^2,4,5, Daniel Alexander², Cath Mummery⁴, Nick Fox⁴, and Geoff JM Parker²

¹MRC Unit for Lifelong Health and Ageing at UCL, University College London, London, United Kingdom, ²Centre for Medical Image Computing, University College London, London, United Kingdom, ³Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ⁴Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ⁵Department of Radiology & Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands

Synopsis

Keywords: Segmentation, DementiaAcquisition time is a crucial factor in the tolerability and availability of MRI examinations for patients attending memory clinics. The suitability of using prototype ultra-rapid sequences for the quantification of white matter hyperintensities was assessed by comparing segmentation outputs from standard clinical and ultra-rapid sequences. Despite a slightly lower sensitivity to smaller lesions, quantification of white matter hyperintensities when using ultra-rapid sequences was very highly correlated with lesion volumes obtained from standard sequences.

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