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Abstract #3587

Improved Brain Lesion Detection by Integrating Subspace-based Deep Learning of Normal Intensity Distributions and Bayesian Hypothesis Testing

Huixiang Zhuang1, Yue Guan1, Yi Ding1, Yuhao Ma1, Yunpeng Zhang1, Ziyu Meng1, Ruihao Liu1,2, Zhi-Pei Liang2,3, and Yao Li1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Synopsis

Keywords: Segmentation, Machine Learning/Artificial Intelligence, Unsupervised learning; Lesion segmentationUnsupervised segmentation of brain lesions is desirable in many applications and has been investigated extensively. In this work, we proposed a new method for brain lesion segmentation, which effectively learns the spatial-intensity distribution of normal brain tissues and then treats lesion segmentation as an anomaly detection problem. We overcame the high-dimensional distribution learning problem using a subspace-assisted generative network. With the learned distribution, the anomaly detection problem was solved using Bayesian hypothesis testing. Our method has been validated using simulated and real brain MR images with stroke and tumor lesions, and produced significantly improved results than several state-of-the-art methods.

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