Abstract #3588

Human brain thalamic nuclei segmentation: compressed-sensing effects on 3D MPRAGE variants

Sebastian Hübner¹, Stefano Tambalo¹, Tobias Kober^2,3,4, and Jorge Jovicich¹

¹Center for Mind/Brain Sciences, University of Trento, Rovereto (Trento), Italy, ²Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, ³Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁴LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Synopsis

Keywords: Segmentation, Brain, ThalamusAccurate segmentation of thalamic nuclei can significantly support clinical decisions, especially in diseases such as Parkinson’s. At the same time, highly accelerated T1w acquisition techniques find wider clinical acceptance as they not only increase radiological efficiency and patient comfort, but also reduce motion artefacts. Here, we study how compressed sensing affects thalamic nuclei volumetry based on MPRAGE or MP2RAGE in healthy subjects with respect to clinical baseline. Segmentation results are promising and agree with expectations: acceleration to about 1 min is possible maintaining overall good image quality, contrast and thalamic segmentations, with acceleration-related biases.

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