Abstract #3597

Reliability of brain volume measurements on 3D-FLAIR is similar to 3D-T1 in multiple sclerosis

David Rudolf van Nederpelt¹, Samantha Noteboom², Eva M.M. Strijbis³, Iman Brouwer¹, Bastiaan Moraal¹, Bas M.S. Jasperse¹, Henk-Jan M.M. Mutsaerts¹, Menno M. Schoonheim², Frederik Barkhof^1,4, Hugo Vrenken¹, and Joost P.A. Kuijer¹

¹Radiology and nuclear medicine, MS Center Amsterdam, Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands, Amsterdam, Netherlands, ²Anatomy and Neurosciences, MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands, Amsterdam, Netherlands, ³MS Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, The Netherlands, Amsterdam, Netherlands, ⁴Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, UK, London, United Kingdom

Synopsis

Keywords: Segmentation, Multiple SclerosisNew methods have enabled segmentation on sequences other than T1 for brain volume measurements in multiple sclerosis (MS), such as those more readily available in clinic as FLAIR and PD. However, reliability studies have not been performed yet in MS, limiting their use. Here, we assessed within-scanner and between-scanner reliability of FLAIR segmentations in 30 people with MS on three different MR scanners. We found similar reliability compared to T1w scans, with high intra-scanner reliability but systematic differences between scanners. This suggests that within-scanner volume measurements of FLAIR are possible, but standardization is needed for between-scanner single patient measurements.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.