Abstract #3598

Comparison of whole brain parenchyma fraction (BPF) from T1W and diffusion MRI in the assessment of CLN3, a neurodegenerative disease

Amritha Nayak^1,2, An N Dang Do³, Audrey E Thurm⁴, Ariane Soldatos⁵, Forbes D Porter³, and Carlo Pierpaoli¹

¹Laboratory on Quantitative Medical Imaging, NIBIB, NIH, Bethesda, MD, United States, ²Henry Jackson Foundation for Advancement of Military Medicine, Bethesda, MD, United States, ³Division of Translational Medicine, NICHD,NIH, Bethesda, MD, United States, ⁴Office of Clinical Director, NIMH,NIH, Bethesda, MD, United States, ⁵Office of Clinical Director, NINDS,NIH, Bethesda, MD, United States

Synopsis

Keywords: Segmentation, Quantitative Imaging, Neurodegeneration, Neurodegeneration diseases, aging, T1-weighted segmentation, T1W, DTI, Diffusion Tensor Imaging, brain parenchyma volume, brain atrophyIn this work, we have compared if whole brain parenchyma fraction (BPF) measured from conventionally used T1-weighted (T1W) based brain segmentation method is comparable to signal fraction attributable to parenchymal water (Par-SF) measured from method using diffusion MRI, in assessing the overall disease state of participants with CLN3, a pediatric neurodegenerative disease.

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