Keywords: Segmentation, Neuroinflammation, White Matter Hyperintensity Segmentation
We propose a tract-specific white matter hyperintensity (WMH) segmentation evaluation as a new way to assess WMH segmentation techniques. Currently, WMH segmentation is assessed globally or between periventricular and deep white matter (WM) regions, which has no obvious functional relevance. WM tracts have known functional relevance and associations to neurological conditions. We demonstrate that this new approach allows for functionally-relevant assessment of techniques. Two WMH segmentation techniques are compared to highlight the performance differences across a key tract associated with processing speed. We also found significant performance differences across this tract, which would be missed by standard evaluation methods.
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