Abstract #3629

Perfusion MRI using dynamic contrast-enhanced MRI and arterial spin labeling for the characterization of small renal masses: preliminary study.

Haitham Al-Mubarak¹, Octavia Bane^1,2, Paul Kennedy¹, Philip Robson¹, Jordan Cuevas^1,2, Arthi Reddy², Kristina Prachanronarong², Kirolos Meilika³, Amir Horowitz⁴, Bernd Kuhn⁵, Steven Sourbron⁶, Ketan Badani³, Bachir Taouli^1,2, and Sara Lewis^1,2

¹BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Precision Immunology Institute/Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Siemens Healthcare, Erlangen, Germany, ⁶University of Sheffield, Sheffield, United Kingdom

Synopsis

Keywords: Cancer, DSC & DCE PerfusionFunctional imaging using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and arterial spin-labeling (ASL), which is a non-contrast technique, have been proposed to quantitatively assess perfusion and vascular flow in small renal masses (SRM) and may provide complementary information. In our initial series, we found significant differences in certain DCE-MRI quantitative and semi-quantitative parameters for renal cell carcinoma (RCC) versus benign tumors (Vp, wash-in, wash-out TTP and AUC) and between ccRCC versus non-clear cell (non-cc)RCC (Ve), while no differences existed between groups for ASL. Certain pharmacokinetic parameters derived from DCE-MRI appear promising for SRM characterization

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