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Abstract #3630

Morphological and Functional Evaluation of Diabetic Kidney Disease Cohorts by using T2-Weighted and Diffusion Weighted MRI

Kaixuan Zhao1,2,3, Sheng Li4, Zhigang Wu5, Thoralf Niendorf6, Wenjian Wang4, and Zaiyi Liu1,3
1Department of Radiology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences,Guangzhou 510080, China, Guangzhou, China, 2Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China, Guangzhou, China, 3Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China, Guangzhou, China, 4Division of Nephrology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China, Guangzhou, China, 5Philips Healthcare Beijing Ltd., Shenzhen, China, 6Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, Berlin, Germany

Synopsis

Keywords: Kidney, KidneyDiabetic Kidney Disease (DKD) is the leading cause of end-stage renal disease worldwide. Morphological evaluation of renal compartment volume changes and functional evaluation of renal ADC changes provide comprehensive insight into DKD disease progression. This study compares renal compartment volume changes including: 1) parenchyma volume ,2) pelvis volume, 3) whole kidney volume and 4) parenchyma volume percentage and the functional parameter ADC for DKD groups with different CKD staging. Our results demonstrate that cortical/medullary ADC, parenchyma volume and whole kidney volume are correlated with eGFR and suggest that the cortical ADC is a stronger predictor of eGFR in DKD.

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