Abstract #3663

Measuring individual vein and artery BOLD responses to visual stimuli in humans with multi-echo single-vessel functional MRI at 7T

Divya Varadarajan^1,2, Paul Wighton^1,2, Jingyuan Chen^1,2, Sebastien Proulx^1,2, Robert Frost^1,2, Andre van der Kouwe^1,2, Avery Berman³, and Jonathan R. Polimeni^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Carleton University, Ottawa, ON, Canada

Synopsis

Keywords: fMRI, Blood vesselsHere we apply single-vessel fMRI techniques to evaluate BOLD and non-BOLD contributions within individual arteries and veins. First we identified individual vessels from inflow effects in a small set of slices, and distinguished arteries and veins on the basis of their T2* decay. Then we applied a high-inplane-resolution multi-echo single-vessel fMRI approach to examine fMRI responses within these vessels. We find evidence for both BOLD and potentially non-BOLD responses within arteries, suggesting that in some cases BOLD may capture arterial responses BOLD which may be more neuronally specific (in space and time) than effects from downstream veins.

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