Abstract #3667

Mapping stimulus-driven hemodynamic changes in white matter using 7T high-resolution fMRI

Jiawen Dakota Fan^1,2, Javier Gonzalez-Castillo³, Peter A. Bandettini^3,4, Jonathan R. Polimeni^2,5,6, and Jingyuan E. Chen^2,5

¹Center for Data Science, New York University, New York City, NY, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ³Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Health, Bethesda, MD, United States, ⁴Functional MRI Core, National Institute of Health, Bethesda, MD, United States, ⁵Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁶Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: fMRI, White MatterIn this study, by integrating 7T high-resolution imaging and massive data averaging, we show that white matter fMRI activations can be detected at a single-voxel level. Hemodynamic changes evoked by the flickering checkerboard stimuli were not homogenous within the optic radiation, and the averaged pattern exhibited a delayed time to peak longer than V1, consistent with previous literature. The current datasets also revealed stimulus-locked changes in certain white-matter tracts beyond the visual pathway.

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