Abstract #3674

Increasing MT contrast in laminar fMRI using PUSH pTx pulses

Viktor Pfaffenrot¹, David Leitao^2,3, Annika Verheyen¹, Markus May^1,4, Raphael Tomi-Tricot⁵, Shaihan Malik^2,6, and David Norris^1,7

¹Erwin L. Hahn Institute for Magnetic Resonance Imaging, University of Duisburg-Essen, Essen, Germany, ²Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ³London Collaborative Ultra high field System (LoCUS), London, United Kingdom, ⁴High Field and Hybrid MR Imaging, University Duisburg-Essen, University Hospital Essen, Essen, Germany, ⁵MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, ⁶Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁷Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands

Synopsis

Keywords: fMRI, Magnetization transfer, laminar fMRIThe GRE-BOLD contrast used in laminar fMRI suffers from suboptimal specificity due to unwanted extravascular effects. Recently, efforts were made to increase specificity of GRE-BOLD by means of CBV-weighting using the magnetization transfer contrast. The specificity improvement depends on the amount of selective GM signal reduction. We investigate whether PUSH pTx pulses, designed to maximize MT contrast in a given area, can achieve a higher functional contrast. Our results suggest that when opting for high-power, off-resonant MT pulses, both PUSH and a CP²⁺ mode perform equally well in increasing the functional contrast at short TE compared to GRE-BOLD in V1.

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