Abstract #3677

Potential of diffusion fMRI for detecting white matter activity in the human brain

Jasmine Khedidja Nguyen-Duc¹, Wiktor Olszowy², Jonathan Patino Lopez ³, and Ileana Jelescu¹

¹Department of Radiology, CHUV, Lausanne, Switzerland, ²CIBM Center for Biomedical Imaging, Lausanne, Switzerland, ³Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Synopsis

Keywords: fMRI (task based), Diffusion/other diffusion imaging techniques, simulations, diffusion fMRIDiffusion functional Magnetic Resonance Imaging (dFMRI) may be used to study the white matter activation in a more direct way than BOLD. The aim of this work is to extract the decrease in apparent diffusion coefficient (ADC) in the white matter observed in real data, and compare to that in a simulation of realistic axon swelling. Results suggest that the decrease is of low amplitude (<0.5%) but nonetheless detectable.

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