Abstract #3685

Short-TE semi-LASER 1H MRS of the primary motor cortex in ALS and controls at 7 Tesla

Zeinab Eftekhari^1,2,3, Thomas B Shaw^1,4,5, Jin Jin^2,6, Kieran O'Brien⁶, Gary Cowin¹, Dinesh K Deelchand⁷, Robert Henderson^5,8, Frederik Steyn^5,8, Sicong Tu⁹, Wolfgang Bogner¹⁰, and Markus Barth^1,2,4

¹Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ²ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, Australia, ³Queensland Brain Institute, The University of Queensland, Brisbane, Australia, ⁴School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia, ⁵Neurology Department, Royal Brisbane and Women’s Hospital, Brisbane, Australia, ⁶Siemens Healthcare Pty Ltd, Brisbane, Australia, ⁷Centre for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ⁸School of Medicine, The University of Queensland, Brisbane, Australia, ⁹Brain and Mind Centre, The University of Sydney, Sydney, Australia, ¹⁰High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria

Synopsis

Keywords: Spectroscopy, Spectroscopy, High-Field MRI, Magnetic Resonance SpectroscopyMagnetic Resonance Spectroscopy (MRS) can offer a unique, non-invasive tool for measuring the neurochemicals in the brain in vivo. This technique may be useful for studying the ratio of metabolites in both health and disease, including in Amyotrophic Lateral Sclerosis (ALS), where differing neuronal populations of the motor cortex are impacted. This study aimed to develop a 7T MRS protocol for ALS patients and measured metabolite ratios in the upper and lower limb regions of the motor cortex at 7T in controls and in ALS. This has the potential to improve progression monitoring and diagnostic certainty in early-stage disease.

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