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Abstract #3688

Localized 31P Magnetic Resonance Spectroscopy of Normal Human Kidneys at 3T

Limin Zhou1, Keith Hulsey1, Durga Udayakumar1,2, Andrea J. Wiethoff3, and Ananth J. Madhuranthakam1,2
1Department of Radiology, University of Texas Southwestern Medical Center, DALLAS, TX, United States, 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, DALLAS, TX, United States, 3Novartis Institutes for BioMedical Research, Cambridge, MA, United States

Synopsis

Keywords: Spectroscopy, Kidney, Phosphorous (31P) MR spectroscopy (MRS), healthy volunteers

Phosphorous (31P) MR spectroscopy (MRS) can measure high energy phosphate metabolism non-invasively in vivo, which can provide metabolic insights into kidney pathophysiology. However, obtaining spectra from healthy volunteers for reference is challenging. In this study, we investigate the feasibility of localized 31P MRS in kidneys of healthy volunteers with a 3T clinical MR scanner. 31P spectra were successfully obtained in 10 healthy volunteers with metabolite ratio calculated to provide information about the energy metabolism.

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Abstract Presentation Video

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