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Abstract #3689

Feasibility of a multi-site and cross-platform liver 31P MRSI processing pipeline for three 7T clinical MRI vendors

Jabrane Karkouri1, Lieke van den Wildenberg2, Bobby Runderkamp3, Jeanine Prompers2, Paolo Cecchi4, Michela Tosetti4,5, Dennis Klomp2, and Christopher T. Rodgers1
1University of Cambridge, Cambridge, United Kingdom, 2Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 4IMAGO7 Research Foundation, Pisa, Italy, 5Laboratory of Medical Physics and Magnetic Resonance, IRCCS Stella Maris, Pisa, Italy

Synopsis

Keywords: Spectroscopy, Non-Proton

We present preliminary baseline results from three-vendor 7 T MRSI for applications on liver 31P MRS. Liver scans were performed on 21 healthy volunteers, at 4 sites and 3 different 7T MR scanner platforms. Data were analysed using a new Matlab pipeline combining the best methods from our labs. This pipeline is operator independent and we report here the liver metabolites as ratios of PME/PDE and Pi/ATP concentrations. The cross-site average PME/PDE was 0.63 ± 0.12, and the cross-site average Pi/ATP was 0.76 ± 0.11. This compares favourably with literature reports [Purvis et. al., 2017].

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