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Abstract #3691

High-Resolution 1H-MRSI of the Brain at 9.4T Integrating Relaxation Enhancement and Subspace Imaging

Yizun Wang1,2, Stanislav S. Rubakhin1,2,3, and Fan Lam1,2,4
1Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Synopsis

Keywords: Spectroscopy, Data Acquisition, MRSI Data ProcessingUltrahigh-field systems offer sensitivity and specificity advantages for metabolite mapping using MRSI. We present here a method that integrates relaxation enhancement acquisition, a unique strategy leveraging higher fields, and subspace imaging, for high-resolution 1H-MRSI at a 9.4 T system. Both in vitro and in vivo experiments have been performed to demonstrate the feasibility of the proposed method. We are able to achieve significantly enhanced SNR compared to no relaxation enhancement and produce high-quality spatially-resolved spectra and high-resolution metabolite images using subspace imaging with 0.6×0.6×2 mm3 nominal resolution in 18 minutes or 1×1×2 mm3 in 10 minutes.

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