Keywords: Spectroscopy, Spectroscopy, in vivo ex vivo MRSThe goal of this study is to demonstrate the feasibility and reliability of metabolite characterization by MR spectroscopy ex vivo in order to maximize the information obtained from a single brain specimen, without the limitations such as scanning time, degraded MRI quality due to intervening tissue and motion artifacts. We demonstrate that ex-vivo spectroscopy obtained after rapid PBS/PFA perfusion is strongly correlated with the MR spectrum previously acquired in the same animal but in vivo but distinct abnormalities due to hypoxia and incomplete fixation do appear; the quality of the spectrum quickly degrades upon longer fixation times.
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