Abstract #3721

A tailored coil for sensitive detection of MRI signals in modulating the rat’s blood-brain barrier by focused ultrasound and microbubbles at 7T

Sheng-Kai Wu^1,2, Alessandro De Maio^1,2, Hsin-Ju Lee^1,2, Kullervo Hynynen^1,2, Meaghan O'Reilly^1,2, and Fa-Hsuan Lin^1,2

¹Sunnybrook Research Institute, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Multimodal, Non-Array RF Coils, Antennas & WaveguidesImaging-guided focused ultrasound using MRI can modulate the permeability of blood-brain barrier with high spatial accuracy. However, many MRI-guided FUS studies rely on either a body coil or head coil poorly suited to the FUS system geometry. We developed a tailored receiver coil to improve the sensitivity of 7T MRI for rats. The tailored geometry allows for a 30% SNR increase in a study modulating the blood-brain barrier permeability with microbubbles.

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