Abstract #3728

ADC Repeatability and Reproducibility of NCI CIRP Network Pre-Clinical MRIs

Dariya Malyarenko¹, Ghoncheh Amouzandeh^1,2, Stephen Pickup³, Rong Zhou³, Henry Charles Manning⁴, Seth T Gamon⁴, Kooresh I Shoghi⁵, James D Quirk⁵, Renuka Sriram⁶, Peder Larson⁶, Michael T Lewis⁷, Robia G Pautler⁷, Paul E Kinahan⁸, Mark Muzi⁸, and Thomas L. Chenevert¹

¹Radiology, University of Michigan, Ann Arbor, MI, United States, ²neuro42, San Francisco, CA, United States, ³Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁴Cancer Systems Imaging, The University of Texas MDACC, Houston, TX, United States, ⁵Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States, ⁶Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ⁷Baylor College of Medicine, Houston, TX, United States, ⁸Radiology, University of Washington, Seattle, WA, United States

Synopsis

Keywords: System Imperfections: Measurement & Correction, Precision & AccuracyThe goal of this work was to assess ADC repeatability, reproducibility, and bias of Co-Clinical Imaging Research Resource Program (CIRP) network MRIs using standardized procedures for comparison to corresponding performance of clinical MRIs. A temperature-controlled phantom provided an absolute reference standard and means to assess spatial uniformity of these metrics. Seven institutions participated in the study where DWI were acquired over multiple days on 10 pre-clinical scanners, from 3 vendors at 6 field strengths. Technical level repeatability and reproducibility metrics, and spatial uniformity patterns are comparable to that observed on human systems using similar phantoms and test procedures.

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