Abstract #3741

manganese-based nanosystem for dual-modality imaging guided STING pathway with immunotherapy against triple-negative breast cancer

Xiuhong Guan¹, Yue Zhao¹, Xin Huang², Zhiyong Wang³, and Ruimeng Yang⁴

¹Department of Radiology, First Affiliated Hospital of Jinan University, Guangzhou, China, ²Guangzhou Medical University, Guangzhou, China, ³School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, China, ⁴Department of Radiology, Guangzhou First People’s Hospital, Guangzhou, China

Synopsis

Keywords: Molecular Imaging, Cancer, tumor, dual-modality imaging, STING pathway, ImmunotherapyDue to the high incidence and mortality rate, breast cancer has become the major cause of cancer death among females. This study reports a kind of functional nanocomposite, which was designed to comprises Pluronic F127 to self-assembly manganese carbonyl (MnCO) and IR780 dyes into one system, exhibiting NIR-II and MR dual-modal imaging guided STING pathway and anti-tumor immunity against triple-negative breast cancer.

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