Keywords: Kidney, Diffusion Tensor ImagingVoxel-based analysis (VBA) can enable voxel-wise statistical analysis of control and disease images without the need for user-defined regions-of-interest (ROI), but has not been widely used beyond neuroimaging. We demonstrate that VBA can be successfully applied to mouse models of renal fibrosis. Diffusion MRI parametric maps of control and disease groups were registered non-linearly to a common coordinate space and VBA successfully identified distinct regions of fibrosis in two different models, which strongly corresponded to whole-kidney histology. VBA therefore has potential in the clinic to identify regions of fibrosis, where whole-kidney histology cannot be obtained.
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