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Abstract #3749

Fractional order calculus model in liver cancer with immunohistochemical indexes CK19 and Hep par-1: a preliminary animal study

Jinhuan Xie1, Liling Long1, Chenhui Li1, and Huiting Zhang2
1The First Affiliated Hospital of Guangxi Medical University, Nanning, China, 2Siemens Healthineers, Wuhan, China

Synopsis

Keywords: Liver, Diffusion/other diffusion imaging techniquesThe purpose of this study was to explore the feasibility of preoperative non-invasive evaluation of immunohistochemical indexes of hepatocellular carcinoma, CK19 and Hep par-1 positive, with Fractional Order Calculus (FROC) model using nude mice model. Results showed that the diffusion coefficient D and fractional order derivative in space β had statistically significant differences and good diagnostic performances between the CK19 and Hep par-1 positive groups. These finding showed that FROC is useful diffusion model and D and β are useful biomarkers in liver cancer with expression of the immunohistochemical indexes CK19 and Hep par-1.

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